The next two decades will be defined by several megatrends: climate and energy, health, geopolitics, digital transformation, AI and automation, and governance. These trends are reshaping critical areas such as sustainable energy, healthcare innovation, global power dynamics, technological disruption, and governance structures. This paper by the Griffith Asia Institute and the United Nations Economic and Social Commission for Asia and the Pacific (ESCAP) explores how these megatrends can profoundly transform the Asia-Pacific region, particularly through the lens of disability inclusion. To ensure these changes benefit everyone—especially marginalised communities such as people with disabilities—policymakers must adopt an inclusive approach to navigating these trends. This paper highlights recommendations for how to do this.